A shed form of LDL receptor–related protein–1 regulates peripheral nerve injury and neuropathic pain in rodents
J. Clin. Invest. Alban Gaultier, et al. 118:161 doi:10.1172/JCI32371 [
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Figure 1Immunohistochemical analysis of LRP1 α-chain in adult mouse and rat sciatic nerve. (
A) LRP1 α-chain in mouse sciatic nerve after CCI. Photomicrographs were prepared at ×400 magnification and are representative of
n = 4/group. Scale bar: 45 μm. The white arrows demarcate Schwann cells that are increasingly immunopositive for LRP1 α-chain after injury. (
B) Immunohistochemical analysis of LRP1 α-chain in rat sciatic nerve after crush injury. Photomicrographs were prepared at ×400 magnification and are representative of
n = 4/group. Sections are of nerve immediately distal to the injury site. The white arrows demarcate Schwann cell cytoplasm that is increasingly immunopositive for LRP1 after injury. (
C) Protein extracts from uninjured and crush-injured rat sciatic nerves were examined by RAP ligand blotting and immunoblot analysis for LRP1 α-chain. The same extracts were probed for β-actin as a loading control. Two representative samples from different animals at each day are shown (
n = 6–9/group).
