Microvascular destruction identifies murine allografts that cannot be rescued from airway fibrosis
J. Clin. Invest. Ashok N. Babu, et al. 117:3774 doi:10.1172/JCI32311 [
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Figure 6VEGFR2 and CXCR2 antagonism lead to early loss of perfusion. Animals administered a CXCR2 antagonist (antileukinate;
n = 3/time point) or a VEGFR2 antagonist (SU5416;
n = 3/time point) were sacrificed at days 6, 8, 10, and 12, and tracheal perfusion was studied by FITC-conjugated lectin perfusion staining. Interestingly, these therapies had no effect on the revascularization occurring by 6 day. However, the loss of perfusion occurred by day 8 rather than by day 10 as in untreated allografts.
