Targeted gene deletion in Candida parapsilosis demonstrates the role of secreted lipase in virulence
J. Clin. Invest. Attila Gácser, et al. 117:3049 doi:10.1172/JCI32294 [
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Figure 8Intraperitoneal and intravenous infection of mice with WT and homozygous
Δcplip1-2/Δcplip1-2, heterozygous
CpLIP1-2/Δcplip1-2, and reconstituted
Δcplip1-2/CpLIP2 mutants.
(
A) CFUs in the kidney, spleen, and liver 2 days after intraperitoneal infection and (
B) 4 days after infection. (
C) CFU counts determined from mice intravenously infected in the kidney, spleen, and liver 2 days after infection. Each box represents 1 mouse. *
P ≤ 0.0049 (Kruskal-Wallis);
#, no detectable CFU. Data are representative of 2 independent experiments.
