IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice
J. Clin. Invest. Pamela Gasse, et al. 117:3786 doi:10.1172/JCI32285 [Go to this article.]

Figure 1
Reduced neutrophil and lymphocyte recruitment in the bronchoalveolar space of BLM-challenged MyD88^–/– and IL-1R1^–/– mice. (A) Total cell counts were augmented at day 1 in BLM-treated WT (B6) mice (15 mg/kg i.n.) and further increased at days 7 and 11 after BLM administration in WT mice, but less so in MyD88^–/– and IL-1R1^–/– mice. (B) Neutrophils were recruited into BALF in WT mice within 24 hours, persisted over 7 days, and normalized on day 11, while only few neutrophils were detected in the absence of MyD88 or IL-1R1. (C) Lymphocytes were found in BALF at day 7 and persisted until day 11 in WT mice and were less prominent in MyD88^–/– and IL-1R1^–/– mice. (D) Alveolar macrophages were augmented at day 11 in WT but not MyD88^–/– or IL-1R1^–/– mice. Data are from 1 experiment representative of 3 independent experiments (n = 4 mice per group; *P < 0.05; **P < 0.01).