Normal human dermis contains distinct populations of CD11c+BDCA-1+ dendritic cells and CD163+FXIIIA+ macrophages
J. Clin. Invest. Lisa C. Zaba, et al. 117:2517 doi:10.1172/JCI32282 [
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Figure 9CD163
+ cells phagocytose large particles and have the structural features of macrophages.
(
A) Tattoo skin section (0.5 μm) stained with toludine blue. Cells containing green tattoo dye in their cytoplasm (black arrow) surrounded a blood vessel. (
B) Electron microscopy of a tattoo showed that dye particles (red arrow) were membrane bound (blue arrow) within the cytoplasm of a cell with multiple microvillus protrusions (green arrow). (
C and
D) Cells containing green tattoo dye particles stained for CD163 (
D) but not BDCA-1 (
C). Scale bar: 10 μm (
A,
C, and
D); 200 nm (
B).