Normal human dermis contains distinct populations of CD11c+BDCA-1+ dendritic cells and CD163+FXIIIA+ macrophages
J. Clin. Invest. Lisa C. Zaba, et al. 117:2517 doi:10.1172/JCI32282 [
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Figure 6Cutaneous DCs compared with blood DCs. (
A) There were 3 nonoverlapping DC populations in peripheral blood, gating on Lin
–CD11c
+HLA-DR
+ cells: BDCA-1
+, CD16
hi, and BDCA-3
+. (
B) Blood BDCA-1
+ (left) and BDCA-3
+ (right) cells were both HLA-DR
+CD14
–. (
C) In dermal single-cell suspensions, BDCA-1
+ cells acquired CD16. (
D) BDCA-1
+ (left) dermal cells increased HLA-DR expression, and BDCA-3
+ (right) dermal cells acquired low-level CD14 expression.