Normal human dermis contains distinct populations of CD11c+BDCA-1+ dendritic cells and CD163+FXIIIA+ macrophages
J. Clin. Invest. Lisa C. Zaba, et al. 117:2517 doi:10.1172/JCI32282 [
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Figure 1FXIIIA
+ and CD11c
+ cells are unique dermal populations.
(
A) Immunohistochemistry on normal human skin using FXIIIA (left panel) and CD11c (right panel) antibodies (
n = 15). FXIIIA
+ cells were spread throughout the dermis, while CD11c
+ cells were mainly localized to the superficial dermis. (
B) There were similar numbers of CD11c
+ and FXIIIA
+ cells per mm in normal dermis. Error bars indicate SEM. (
C) FXIIIA and CD11c identified 2 discrete populations. White lines denote dermo-epidermal junction. Scale bars: 100 μm.