ErbB receptors: from oncogenes to targeted cancer therapies
J. Clin. Invest. Hongtao Zhang, et al. 117:2051 doi:10.1172/JCI32278 [Go to this article.]

Figure 2
Molecules in the ErbB signaling pathways as targets for cancer therapies. FDA-approved drugs include three mAbs targeting the extracellular domain of ErbB and three TKIs targeting the kinase domains. Trastuzumab targets p185^her2/neu. Cetuximab and panitumumab target EGFR. Some TKIs (gefitinib, erlotinib) are only specific for EGFR, while lapatinib and HKI-272 also broadly inhibit other receptors in the family. Inhibitors to molecules downstream of ErbB signaling pathways, such as Src, AKT, survivin, and mTor, are also potential therapeutics for ErbB-mediated transformation. AHNP-SA, AHNP-streptavidin; scFv, single-chain variable fragment.