Angiogenesis modulates adipogenesis and obesity
J. Clin. Invest. Yihai Cao, et al. 117:2362 doi:10.1172/JCI32239 [Go to this article.]

Figure 1
Regulation of adipose tissue angiogenesis by multiple factors. Diversity of cell populations in the adipose tissue, including preadipocytes and adipocytes, ASCs, and inflammatory cells contributes to production of multiple angiogenic factors and inhibitors that regulate adipose angiogenesis. Interplay between different factors could result in angiogenic synergism. For example, leptin and VEGF-A or FGF-2 could synergistically stimulate angiogenesis. Tissue hypoxia could further upregulate expression levels of VEGF and leptin. MMPs could increase bioavailability of angiogenic factors by release of the matrix-bound VEGF.