Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic β cells
J. Clin. Invest. Lingwen Zhong, et al. 117:2869 doi:10.1172/JCI32198 [
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Figure 7Adaptive expansion of β cell mass was abrogated in
Skp2–/– mice.
(
A) Analysis of β cell mass 12 weeks after feeding with HFD or ND.
n = 3 per group. (
B–
E) Pancreatic sections from
Skp2+/– mice (
B and
D) and
Skp2–/– mice (
C and
E) fed HFD for 12 weeks were immunostained with antibodies to insulin (green) and to β-catenin (red) (
B and
C), or to insulin (green) and Ki-67 (red) (
D and
E). Arrows denote proliferating β cells. DAPI-stained nuclei appear blue. *
P < 0.05; **
P < 0.01.
