Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic β cells
J. Clin. Invest. Lingwen Zhong, et al. 117:2869 doi:10.1172/JCI32198 [Go to this article.]

Figure 6
Skp2^–/– mice failed to compensate for diet-induced insulin resistance. (A) Insulin tolerance test 12 weeks after feeding with HFD or ND (55% and 12.2% calories from fat, respectively). n = 5. HFD-fed mice were compared with ND-fed mice. P < 0.03 (20 minutes); P < 0.003 (40 minutes); P < 0.005 (60 minutes). (B) When insulin tolerance test was represented as area under the curve, the mice fed HFD were significantly insulin insensitive compared with mice fed ND. P < 0.13 between groups fed ND; P < 0.27 between groups fed HFD; P < 0.009 between Skp^+/– groups; P < 0.006 between Skp^–/– groups. (C) Blood glucose level after overnight fasting. Fasting blood glucose over 200 mg/dl was defined as diabetes. n = 5 (Skp2^+/– ND and Skp2^–/– ND); 8 (Skp2^+/– HFD); 6 (Skp2^–/– HFD). (D) Glucose tolerance test 12 weeks after feeding with HFD. *P < 0.05; **P < 0.01; ***P < 0.005.