Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic β cells
J. Clin. Invest. Lingwen Zhong, et al. 117:2869 doi:10.1172/JCI32198 [
Go to this article.]
Figure 4The absence of
Skp2 does not affect insulin content and glucose-stimulated insulin secretion of β cells.
(
A and
B) Insulin content of
Skp2+/– and
Skp2–/– β cells, which were normalized to pancreas weight (
A) or to β cell mass (
B).
n = 3 per group. (
C) Glucose-induced insulin secretion of
Skp2+/– and
Skp2–/– β cells was detected by in vitro islet perifusion assay. **
P < 0.01.
