Type I IFN innate immune response to adenovirus-mediated IFN-γ gene transfer contributes to the regression of cutaneous lymphomas
J. Clin. Invest. Mirjana Urosevic, et al. 117:2834 doi:10.1172/JCI32077 [Go to this article.]

Figure 4
Classification of the skin lesions using OR predictor genes. The heatmap was obtained by unsupervised hierarchical clustering of the baseline and posttreatment 3 data using 45 predictor genes. The similarity of gene expression profiles among experimental samples is summarized in a dendrogram above the heatmap, in which the pattern and the length of the branches reflect the relatedness of the samples. Black dendrogram branches represent baseline samples; blue branches represent posttreatment 3 samples. Red in the heatmap stands for high relative level of expression; green for low relative level of expression. Genes are identified by their gene symbols (NetAffx). To the right of each gene symbol, the prediction strength of each gene is represented by gray-shaded bars. Positive intralesional transgene expression is shown by black squares, whereas white squares represent no transgene expression. Objective clinical response of the treated lesion is represented by violet squares, whereas lack of OR is represented by yellow squares.