Endothelial sulfonylurea receptor 1–regulated NC_Ca-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury
J. Clin. Invest. J. Marc Simard, et al. 117:2105 doi:10.1172/JCI32041 [Go to this article.]

Figure 4
Blocking SUR1 reduces lesion size and improves neurobehavioral function after SCI. (A–C) Cord sections immunolabeled for glial fibrillary acidic protein (A) or stained with eriochrome cyanine R (B) or H&E (C), 1 day (A and B) or 7 days (C) after SCI, from vehicle-treated and glibenclamide-treated rats. Images are representative of findings in 3 rats per group. Scale bars: 1 mm. (D) Cascaded outlines of lesion areas in serial sections 250 μm apart, 7 days after SCI, as well as lesion volumes from vehicle-treated and glibenclamide-treated rats (n = 4–6 per group; excludes 2 control rats that died). (E) Performance on inclined plane (head up and head down), ipsilateral paw placement, and rearing in the same vehicle-treated and glibenclamide-treated rats as in D. Paw placement was measured 1 day after SCI. Error bars indicate SEM. *P < 0.05, **P < 0.01, ***P < 0.001 versus control.