Genomics and the evolution, pathogenesis, and diagnosis of tuberculosis
J. Clin. Invest. Joel D. Ernst, et al. 117:1738 doi:10.1172/JCI31810 [Go to this article.]

Figure 2
The RD1 locus and components of the ESX-1 secretion system. ESAT-6 and CFP-10 dimer secretion (A) by M. tuberculosis depends on other genes in the RD1 locus (B). The product of Rv3870 is a membrane protein that interacts directly with Rv3871, a predicted cytoplasmic protein. Based on homology to the SpoIIIE/FtsK family, Rv3870 and Rv3871 are thought to form a membrane-bound ATPase that provides energy for export of secretion substrates; the carboxyl terminus of CFP-10 interacts directly with the carboxyl terminus of Rv3871. Rv3877 encodes a protein with 12 membrane-spanning domains and is likely to form a secretion pore. Rv3876 is essential for secretion of CFP-10 and ESAT-6 dimers, but its role has not been determined. Secretion substrates encoded by genes outside the BCG RD1 locus include the product of Rv3616c (57), and additional genes essential for ESAT-6 secretion that are outside of the BCG RD1 include Rv3614c, Rv3615c, and Rv3616c (57, 60). The products of Rv3614c and Rv3882c have been found to directly interact (60).