Genomics and the evolution, pathogenesis, and diagnosis of tuberculosis
J. Clin. Invest. Joel D. Ernst, et al. 117:1738 doi:10.1172/JCI31810 [
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Figure 1Evolutionary scheme for the
M. tuberculosis complex.
The phylogenetic scheme is based on informative markers present or absent in the progeny of each lineage. Markers in boxes include lost RD regions, SNPs, lost spoligotype spacers, and deletions in the
pks15/1 and TbD1 loci. The seven species of the
M. tuberculosis complex and their respective natural hosts are shown, as well as the three principal genetic groups of
M. tuberculosis and their representative strains. Adapted with permission from the
Journal of Theoretical Biology (
1),
Proceedings of the National Academy of Sciences of the United States of America (
11), and
Microbiology (
16).
