Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease
J. Clin. Invest. Sung-Rae Cho, et al. 117:2889 doi:10.1172/JCI31778 [Go to this article.]

Figure 1
AdBDNF induced striatal neuronal recruitment in both R6/2 and WT mice. At 1 mo after AdBDNF injection (6 wk), R6/2 striata were double-stained for BrdU (green) and βIII-tubulin (red, A), NeuN (red, B), GAD67 (red, C), or DARPP-32 (red, D). Identically treated WT mice stained for the same markers are shown in E–H. Colabeling of BrdU with each neuronal marker was confirmed by confocal optical sectioning, with orthogonal views in the xz and yz planes (insets). Arrowheads denote double-labeled cells. Scale bars: 10 μm.