Enhanced at puberty 1 (EAP1) is a new transcriptional regulator of the female neuroendocrine reproductive axis
J. Clin. Invest. Sabine Heger, et al. 117:2145 doi:10.1172/JCI31752 [Go to this article.]

Figure 1
EAP1 mRNA abundance increases in the nonhuman primate and rat hypothalamus at the time of puberty. (A) Puberty-related increase in EAP1 mRNA content in the hypothalamus of female rhesus monkeys detected using human cDNA microarrays. Changes in mRNA content are expressed as fold increase over values present in prepubertal juvenile (Juv) animals. EP, early puberty; MP, mid-puberty. (B) EAP1 mRNA abundance increases in the MBH of female rhesus monkeys at the time of puberty, as assessed by real-time PCR. (C) EAP1 mRNA content does not increase in the CTX. ***P < 0.01 versus Juv control. (D) Abundance of the mRNA encoding the EAP1 homolog CAB45750 does not change in the MBH at the time of puberty. EAP1 mRNA content increases in the MBH (E), but not in the CTX (F), of female rats at the time of puberty, as assessed by semiquantitative PCR. Numbers above bars represent number of animals per group, and error bars are SEM. **P < 0.02 versus Juv control. Filled circles in A represent the range of values reported in the 2 microarrays and that were subsequently used to compare EP and MP animals with the Juv group; open circles in panel C represent the individual values of the only 2 animals used in this group.