HIF-1 and HIF-2: working alone or together in hypoxia?
J. Clin. Invest. Peter J. Ratcliffe, et al. 117:862 doi:10.1172/JCI31750 [Go to this article.]

Figure 2
Cooperative interactions at the Epo locus that are proposed to direct preferential binding of HIF-2α. While the isolated HRE preferentially binds HIF-1α (A), in this issue of the JCI Rankin et al. (8) show that HIF-2α binds preferentially at the HRE within the native Epo 3' enhancer (B) and propose that cooperative interactions with other transcription factors bound to the 3' enhancer, to the promoter, or to other cis-acting sequences enable HIF-2α to bind preferentially to this HRE. The position of a hepatic nuclear factor–4 (HNF-4) binding site within the enhancer, which is a candidate participant in this action, is marked.