Sickle cell disease: old discoveries, new concepts, and future promise
J. Clin. Invest. Paul S. Frenette, et al. 117:850 doi:10.1172/JCI30920 [Go to this article.]

Figure 1
Sickle erythrocytes. Peripheral blood smear from a patient with SCD obtained during a routine clinic visit. The smear shows classical sickle-shaped (arrows) and various other misshaped erythrocytes (arrowheads). The image was obtained from an air-dried smear using differential interference contrast (DIC) microscopy with an Olympus BX61WI work station equipped with a LUMPlanFI ×60 numerical aperture 0.90 ∞ objective (Olympus) and a CoolSnap HQ camera (6.6 μm² pixel, 1,392 × 1,040 pixel format) (Roper Scientific). Scale bar: 10 μm.