Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair
J. Clin. Invest. Christopher B. Little, et al. 117:1627 doi:10.1172/JCI30765 [Go to this article.]

Figure 4
Aggrecan degradation in vitro. (A) Aggrecan release from wild-type (white bars) and Jaffa (gray bars) cartilage cultured with or without 10 ng/ml IL-1α (n = 8–10 per treatment). Results are mean ± SEM. The dotted line shows the level of baseline release. ***P < 0.001. (B) Cartilage extracts from wild-type and Jaffa mice with or without IL-1α treatment were analyzed by Western blot. Membranes were immunolocalized for VTEGE³⁷³ neoepitope.