Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes
J. Clin. Invest. Valeriya Lyssenko, et al. 117:2155 doi:10.1172/JCI30706 [
Go to this article.]
Figure 4Expression of
TCF7L2 in human pancreatic islets was influenced by T2D and correlates positively with insulin gene expression and negatively with insulin secretion.
(
A) The
TCF7L2 mRNA levels in human pancreatic islets. (
B) The
TCF7L2 mRNA levels in different
TCF7L2 rs7903146 genotype carriers. (
P refers to ANCOVA comparison between CC, CT, and TT genotypes) (
C) Correlation between the
TCF7L2 mRNA levels and insulin gene expression. (
D) Correlation between the
TCF7L2 mRNA levels and glucose-stimulated insulin release (stimulation index). Bars represent mean ± SEM.
