Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes
J. Clin. Invest. Valeriya Lyssenko, et al. 117:2155 doi:10.1172/JCI30706 [
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Figure 1Diabetes-free survival (Kaplan-Meier curves) in carriers of different
TCF7L2 rs7903146 genotypes.
(
A) Diabetes-free survival in the MPP (
n = 6,913). (
B) Diabetes-free survival in the Botnia study (
n = 2,651). The blue lines represent carriers of non-risk CC genotype; the red lines represent carriers of the risk CT/TT genotypes. 95% CIs are from logistic regression analyses adjusted for age at entry and time of follow-up, BMI, sex, and family history of diabetes.