Homeostatically proliferating CD4⁺ T cells are involved in the pathogenesis of an Omenn syndrome murine model
J. Clin. Invest. Khie Khiong, et al. 117:1270 doi:10.1172/JCI30513 [Go to this article.]

Figure 3
T and B cell development in MM mice is inhibited at receptor gene rearrangement stages. (A) The memory/activated phenotype of CD4⁺ and CD8⁺ T cells in the spleen was analyzed by FACS. Numbers denote percentage of cells within the indicated gates or bracketed ranges. (B) The percentage and number of CD4⁺ (P < 0.001 and P < 0.001, respectively) and CD8⁺ (P = 0.001 and P < 0.001, respectively) T cells in the spleen was lower in MM than in wild-type mice. The percentages of CD8⁺CD69⁺ (P = 0.006), CD8⁺CD25⁺ (P = 0.001), CD8⁺CD44⁺ (P < 0.001), CD8⁺CD122⁺ (P < 0.001) and CD4⁺CD69⁺ (P = 0.02), CD4⁺CD25⁺ (P = 0.001), CD4⁺CD44⁺ (P = 0.02), and CD8⁺CD122⁺ (P < 0.001) cells were higher in MM than in wild-type mice. Data were calculated using the FACS profiles in A. (C) The percentage and number of bone marrow B220⁺IgM^– (P = 0.03 and P < 0.001, respectively) and B220⁺IgM⁺ (P = 0.01 and P = 0.02, respectively) cells as well as splenic B220⁺IgM⁺ cells (P < 0.001 and P = 0.002, respectively) were lower in MM mice than in wild-type mice. *P < 0.05, ^#P < 0.01, ^†P < 0.001 versus wild type.