Revertant mosaicism in junctional epidermolysis bullosa due to multiple correcting second-site mutations in LAMB3
J. Clin. Invest. Anna M.G. Pasmooij, et al. 117:1240 doi:10.1172/JCI30465 [Go to this article.]

Figure 2
IF microscopy reveals cellular mosaicism in the skin of proband 078-01. (A and B) Staining with monoclonal antibody K140 to the β3 chain of LM-332 was markedly reduced in affected skin of the upper arm (A) compared with normal control skin (B). (C) To our surprise, a short stretch of approximately 25 basal cells embedded in an LM-332–reduced environment that stained brightly for LM-332 was observed in biopsy II (M). (D) Biopsy III (R) of the left lower leg showed an interrupted pattern, with normal and reduced staining along the epidermal-dermal junction, while biopsy IV (R) revealed bright staining for all basal cells (data not shown). Original magnification, ×40.