Role of Gas6 in erythropoiesis and anemia in mice
J. Clin. Invest. Anne Angelillo-Scherrer, et al. 118:583 doi:10.1172/JCI30375 [
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Figure 3Erythropoietic response to acute anemia in WT (black lines) and
Gas6–/– (red lines) mice.
P values above the graphs denote overall genotypic difference during the entire period of analysis, as analyzed by ANOVA for repeated measurement statistics. *
P < 0.05, standard
t test. (
A–
D) Impaired erythropoiesis in
Gas6–/– compared with WT mice in response to PHZ-induced hemolytic anemia. (
A and
B) Hematocrit levels (
A) and reticulocyte indices (
B) after 2 PHZ injections on days 0 and 1 (
n = 8). Data were reproduced in 100% C57BL/6 background (Supplemental Figure 1). (
C and
D) Impaired erythropoiesis in
Gas6–/– mice in response to autoimmune hemolytic anemia, induced by intraperitoneal injection of the 34-3C anti-mouse rbc monoclonal antibody (200 μg on day 0). (
C) Hematocrit levels. (
D) Reticulocyte indices (
n = 8). (
E) Impaired erythropoiesis in
Gas6–/– splenectomized mice in response to injections of PHZ injections on days 0 and 1 (
n = 6). (
F) Hematocrit levels in
Gas6–/– and WT mice after PHZ injections on days 0, 1 and 2 (
n = 6). A hematocrit value of 11% (the lowest detectable hematocrit level in preterminal mice) was assigned to the mice that died in the course of the experiment. Values are mean ± SEM.
