Role of Gas6 in erythropoiesis and anemia in mice
J. Clin. Invest. Anne Angelillo-Scherrer, et al. 118:583 doi:10.1172/JCI30375 [Go to this article.]

Figure 1
Defects in the erythroid lineage of WT and Gas6^–/– mice. (A and B) Reduced number of erythroid progenitors in fetal liver of Gas6^–/– mice, analyzed as the number of BFU-Es (A) or CFU-Es (B). n = 6 per group. *P < 0.05. (C and D) Reduced percentage of Ter-119⁺ nucleated cells (erythroblasts) in adult BM (C; *P = 0.02) and spleen (D; *P < 0.02) in Gas6^–/– mice. The erythroblasts were quantified as the percent of all nucleated cells by flow cytometry. n = 9 per group. (E and F) Reduced number of erythroid progenitors in the BM of adult Gas6^–/– mice, analyzed as the number of BFU-Es (E) or CFU-Es (F). n = 8 per group. *P < 0.05. Values are mean ± SEM.