Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice
J. Clin. Invest. Alexander Pfeifer, et al. 116:3204 doi:10.1172/JCI29236 [
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Figure 3Survival times of LVsh512-chimeric and control mice after Rocky Mountain Laboratory Inc. (RML) scrapie infection. Chimeric mice derived from LVsh512-derived ES cells survived prion disease up to 231 days. All control animals (GFP.3, green; C57×129sv, black; 129sv, blue) died within 174 dpi with prions. Dashed lines, controls; Red line, LVsh512-chimeric mice.
