Neuropeptide signaling and hydrocephalus: SCO with the flow
J. Clin. Invest. David J. Picketts, et al. 116:1828 doi:10.1172/JCI29148 [Go to this article.]

Figure 2
Schematic diagram modeling flow through the Sylvian aqueduct in WT and PAC1 receptor transgenic mice. (A) In WT mice, ependymal cells from the SCO secrete glycoproteins that form RF and help maintain laminar flow of the CSF through the aqueduct. Cilia on the vel cells also promote CSF flow. (B) In transgenic animals, there are fewer SCO cells, which may result in absent or disorganized RF but not stenosis of the aqueduct. In addition, shorter, inefficient cilia are present on the vel cells. Together, these defects likely result in turbulent CSF flow at the entrance (curved arrows) and reduced flow within (dashed arrows) the cerebral aqueduct, thereby promoting hydrocephalus.