Embryonic endocrine pancreas and mature β cells acquire α and PP cell phenotypes upon Arx misexpression
J. Clin. Invest. Patrick Collombat, et al. 117:961 doi:10.1172/JCI29115 [Go to this article.]

Figure 5
Arx misexpression converts mature β cells into glucagon- or PP-producing cells. (A–D) Representative staining and quantification of the endocrine cell content alterations found in tamoxifen-treated cArxOE::IndPdx1Cre pancreata with the use of the indicated antibodies. (E) Co-immunohistochemical detection of the glucagon (blue) and PP hormones (green) with the β-galactosidase enzyme (red). Note that glucagon- or PP-producing cells are positive for the β-galactosidase. Each picture is representative of 4–7 animals from different litters. Original magnification, ×40.