Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy
J. Clin. Invest. Antoine Muchir, et al. 117:1282 doi:10.1172/JCI29042 [
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Figure 6Time-course expression of genes activated by MAPK in hearts from
LmnaH222P/H222P mice at 4, 7, and 10 weeks of age.
Expression of
Myl7,
Vegf,
Sln,
c-Jun,
Elk1,
JunD, and
Elk4 in hearts of
Lmna+/+ and
LmnaH222P/H222P mice is shown. Bars indicate the fold overexpression of the indicated mRNA normalized to
Gapdh as calculated by the ΔδC
T method. Values are mean ± SD for 6 samples per group (*
P < 0.05, **
P < 0.005).
