Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy
J. Clin. Invest. Antoine Muchir, et al. 117:1282 doi:10.1172/JCI29042 [
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Figure 5Expression of
c-Jun,
Elk1,
JunD, and
Elk4 in various tissues from 10-week-old
Lmna+/+ and
LmnaH222P/H222P mice.
Summary of real-time PCR results in heart, skeletal muscle (sk. muscle), lung, spleen, and bladder are shown. Bars indicate the fold overexpression of the indicated mRNA normalized to
Gapdh as calculated by the ΔδC
T method. Values are mean ± SD for 6 samples per group (*
P < 0.05, **
P < 0.005).
