Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy
J. Clin. Invest. Antoine Muchir, et al. 117:1282 doi:10.1172/JCI29042 [Go to this article.]

Figure 2
Histological analysis of heart muscle in Lmna H222P mice and expression of myosins and ANF. (A) Histological analysis of hearts from 10-week-old control Lmna^+/+ and Lmna^H222P/H222P mice. Representative fixed sections of left ventricles stained with H&E (upper panels) and Gomori’s trichrome (lower panels) are shown. Note normal-appearing cardiomyocytes and absence of fibrosis. Scale bars: 50 μm. (B) Expression of myosins and ANF in hearts of 10-week-old Lmna^+/+, Lmna^H222P/+, and Lmna^H222P/H222P mice. Representative immunoblots for ANF, β-MHC, and MLC-2 are shown. β-tubulin Ab was used as a loading control. Data in bar graphs are mean ± SD for 5 samples per group (*P < 0.05).