Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony
J. Clin. Invest. Mark A. Herman, et al. 116:1767 doi:10.1172/JCI29027 [
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Figure 2Intertissue glucose sensing and communication. Glucose is sensed in numerous tissues and cell types, including the hypothalamus, hepatocytes, the hepatoportal sensor, pancreatic islets, and possibly muscle and adipose tissue, each of which communicates with other tissues via hormones, neural pathways, or changes in the utilization of substrate. Pink lines represent neural mediated communication. Black lines represent glucose- or hormone-mediated communication.