Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin
J. Clin. Invest. Luke J. Engelking, et al. 116:2356 doi:10.1172/JCI28988 [Go to this article.]

Figure 2
Craniofacial abnormalities of Insig-DKO embryo. Male and female Insig-1^+/–Insig-2^–/– mice were mated, and the resultant embryos were collected at 18.5 dpc, photographed, and genotyped. Lateral (A) and palatal views (B) of control (Insig-1^+/+Insig-2^–/– littermate) and Insig-DKO embryos with cleft palate or cleft face. The lower jaw was resected to reveal the oral cavity. Black arrows indicate cleft palate; white arrows indicate cleft face. pa, palate; tg, tongue. Scale bars: 2.5 mm.