PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR
J. Clin. Invest. Hongbing Zhang, et al. 117:730 doi:10.1172/JCI28984 [
Go to this article.]
Figure 6Tsc1-null and Tsc2-null MEFs have reduced tumorigenic potential. Tumor development and survival curves are shown for immunodeficient nude mice after subcutaneous inoculation with 1 × 10
6 MEFs. Mice receiving
Tsc1–/– cells (
A) or
Tsc2–/– cells (
B) had delayed tumor formation and a longer survival than mice receiving control cells. All cells used in
B were deficient in tumor suppressor gene
TP53.
