Rai1 duplication causes physical and behavioral phenotypes in a mouse model of dup(17)(p11.2p11.2)
J. Clin. Invest. Katherina Walz, et al. 116:3035 doi:10.1172/JCI28953 [
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Figure 3Genomic balance corrects learning and memory deficits. The percentages of freezing to context [
F(3, 46) = 10.847,
P < 0.0001] (
A) and the sound cue (
P > 0.05) (
B) are represented for each of the 4 genotypes tested. Note that the abnormal freezing of
Dp(11)17/+ animals was corrected in
Dp(11)17/Df(11)17 mice. Black bars, wild type; light gray bars,
Dp(11)17/+; dark gray bars,
Df(11)17/+; white bars,
Dp(11)17/Df(11)17. The mean ± SEM values are presented. Actual values are given in Supplemental Table 2. **
P < 0.01 compared with wild type.
