Rai1 duplication causes physical and behavioral phenotypes in a mouse model of dup(17)(p11.2p11.2)
J. Clin. Invest. Katherina Walz, et al. 116:3035 doi:10.1172/JCI28953 [
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Figure 2Genomic balance restores normal behavior. The results of 3 different parameters that were measured in the open-field paradigm (vertical activity, center/total distance, and total distance) are represented as bar graphs for each of the 4 genotypes tested. (
A) Vertical activity [
F(3, 46) = 26.9;
P < 0.0001]. (
B) Center/total distance ratio [
F(3, 46) = 6.740;
P = 0.001]. (
C) Total distance (cm) [
F(3, 46) = 4.260;
P = 0.01]. Note that the abnormal vertical activity and center/total distance ratio observed in
Dp(11)17/+ animals was normalized after restoration of genomic balance [i.e.,
Dp(11)17/Df(11)17]. Black bars, wild type; light gray bars,
Dp(11)17/+; dark gray bars,
Df(11)17/+; white bars,
Dp(11)17/Df(11)17. Values represent mean ± SEM. Actual values are given in Supplemental Table 2. *
P < 0.05, **
P < 0.01 compared with wild-type littermate.
