Rai1 duplication causes physical and behavioral phenotypes in a mouse model of dup(17)(p11.2p11.2)
J. Clin. Invest. Katherina Walz, et al. 116:3035 doi:10.1172/JCI28953 [Go to this article.]

Figure 1
Representation of the genomic region duplicated in Dp(11)17. A schematic representation of the 17p11.2 region of human chromosome 17 and the 32- to 34-cM interval of the syntenic region of mouse chromosome 11 is shown. The gray circles depict the centromeres. The horizontal black line (bottom) denotes the genomic interval encompassing the Dp(11)17 duplication generated by chromosomal engineering. Note that the numbers, orientations, and relative orders of the genes in these syntenic genomic intervals are extremely conserved. Three low-copy repeats are present in the human region: SMS-REPD (distal); SMS-REPM (middle); SMS-REPP (proximal). The mouse Rai1 and human RAI1 genes are indicated in boxes.