A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo
J. Clin. Invest. Helen S. Bell, et al. 117:1008 doi:10.1172/JCI28920 [
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Figure 237AA causes selective killing of tumor cells. Tumor cell lines LoVo (
A and
B) and HeLa (
C and
D) as well as primary cell cultures MEF (
E and
F), HFF (
G and
H), and RPE (
I and
J) were transfected or infected with the indicated transgenes. After 48 hours (transfection,
A–
D) or 72 hours (infection,
E–
K), transgene expression was assessed by Western blotting (
A,
C,
E,
G, and
I), and the effects on cell death were determined by flow cytometry (
B,
D,
F,
H,
J, and
K).
