TLR4 links innate immunity and fatty acid–induced insulin resistance
J. Clin. Invest. Hang Shi, et al. 116:3015 doi:10.1172/JCI28898 [
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Figure 8Female mice lacking TLR4 show increased obesity but are partially protected against high-fat diet–induced (HFD-induced) insulin resistance, and HFD does not induce inflammatory gene expression in fat and liver in these mice. (
A) Body weights of WT and
TLR4–/– mice on HFD or chow diet. (
B) Lean and fat tissue weight as assessed by dual-energy x-ray absorptiometry at 26 weeks on HFD. (
C) Cumulative food intake. Daily food intake was measured for 1 week after 22 weeks on diet. (
D) Insulin tolerance test. Insulin (1 mU/g BW) was administered to mice after 36 weeks on diet. HFD induces inflammatory gene expression in fat (
E) and liver (
F) in WT but not TLR4-knockout mice. Data are expressed as mean ± SEM (
n = 7–9). *
P < 0.05, WT versus
TLR4–/–;
#P < 0.05 between groups as indicated.
