TLR4 links innate immunity and fatty acid–induced insulin resistance
J. Clin. Invest. Hang Shi, et al. 116:3015 doi:10.1172/JCI28898 [
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Figure 7TLR4 deficiency prevents lipid-induced insulin resistance. Mice were fasted overnight and preinfused with lipid for 5 hours. (
A) Schematic diagram of lipid infusion and hyperinsulinemic-euglycemic clamp studies. Hyperinsulinemic-euglycemic clamps were conducted to examine the effect of lipid infusion on insulin sensitivity in
TLR4–/– and WT mice. (
B) Glucose infusion rate. (
C) Insulin-stimulated glucose turnover rate. (
D) Insulin-stimulated glucose uptake in skeletal muscle (gastrocnemius). (
E) Insulin-stimulated glucose uptake in white adipose tissue (epididymal fat). (
F) Insulin-stimulated whole-body glycolysis. All data are expressed as mean ± SEM;
n = 4–10; *
P < 0.05.
