PLCγ2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2
J. Clin. Invest. Dailing Mao, et al. 116:2869 doi:10.1172/JCI28775 [Go to this article.]

Figure 2
Osteopetrosis in mice lacking PLCγ2. (A) TRAP staining of decalcified histological sections of WT and Plcg2^–/– proximal femurs. Magnification, ×40. (B–E) Quantitative analysis of bone parameters from histological sections of WT and Plcg2^–/– bone femurs (n = 8) showing: percentage of bone volume versus total bone volume (BV/TV) (B); number of OBs (nOB) per bone perimeter (C); number of OCs (nOC) per bone perimeter (D); fraction of trabecular surface covered by OCs (E). (F) 3D reconstitution of μCT scans of WT and Plcg2^–/– femurs. (G–I) 3D trabecular quantitative parameters of bone structure (n = 6). Graphs show mean ± SEM, with significant differences compared with WT indicated.