Oxidative stress mediates tau-induced neurodegeneration in Drosophila
J. Clin. Invest. Dora Dias-Santagata, et al. 117:236 doi:10.1172/JCI28769 [Go to this article.]

Figure 4
Tau^R406W transgenic flies are more sensitive to oxidative injury than age-matched controls. One-day-old flies were exposed to no drug or to 30 mM paraquat, and survival was scored after 48 hours. Compared with use of drug-free medium, administration of paraquat resulted in significant lethality for control flies (***P < 0.001) and for tau^R406W transgenic flies (***P < 0.001). Tau^R406W-expressing flies were significantly more sensitive to 30 mM paraquat (P < 0.001) than controls. Genotypes are as follows: control, elav-GAL4/+; and tau^R406W, elav-GAL4/+, UAS-tau^R406W/+.