Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in mice
J. Clin. Invest. Sandrine Billet, et al. 117:1914 doi:10.1172/JCI28764 [
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Figure 7Functional and morphological characterization of AT
1AWT and AT
1AMUT mouse kidney.
Kidney function was evaluated by measuring 24-hour urinary creatinine (
A) and Na/K balance (
B) for 3 days. All assays were performed in AT
1AWT (white bars) and AT
1AMUT (black bars) mice fed a normal-sodium diet. (
C) Representative kidney histological sections from both mice genotypes stained with Sirius red. Scale bars: 10 μm. (
D) Quantitative RT-PCR of collagen αI and PAI1 mRNA in AT
1AWT (white bars) and AT
1AMUT (black bars) kidneys. *
P < 0.05 compared with AT
1AWT.
