Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in mice
J. Clin. Invest. Sandrine Billet, et al. 117:1914 doi:10.1172/JCI28764 [
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Figure 6Renin-angiotensin-aldosterone system parameters. Plasma renin (
A), plasma immunoreactive angiotensin (
B), and plasma aldosterone (
E) concentrations were determined in AT
1AWT mice (white bars) and AT
1AMUT mice (black bars). (
C) Representative in situ hybridization detection of renin expression in kidney sections from AT
1AWT and AT
1AMUT adult (
C) and neonate (
D) animals. The juxtaglomerular apparatus is indicated by arrows. Relative hyperaldosteronism was also evaluated by computing the aldosterone/renin ratio (
F). *
P < 0.05, ***
P < 0.001 compared with AT
1AWT.
