Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in mice
J. Clin. Invest. Sandrine Billet, et al. 117:1914 doi:10.1172/JCI28764 [
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Figure 5Systolic BP measured by the tail-cuff method. (
A) Systolic BP measured throughout the lives of AT
1AWT mice (white bars) and AT
1AMUT mice (black bars). **
P < 0.01 compared with AT
1AWT. (
B) Systolic BP measurements after candesartan treatment. Animals were treated with candesartan in drinking water (10 mg/kg/d) for 25 days. Systolic BP was measured as above on the last 3 days of the treatment period. **
P < 0.01 compared with untreated animals.
