Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in mice
J. Clin. Invest. Sandrine Billet, et al. 117:1914 doi:10.1172/JCI28764 [Go to this article.]

Figure 4
Pressor response to Ang II of AT_1AWT and AT_1AMUT mice. Effect of cumulative intravenous bolus doses of Ang II on BP in anesthetized mice. (A) Representative recordings, following Ang II injections (arrows), of systolic (red), mean (blue), and diastolic (green) BPs in AT_1AWT and AT_1AMUT mice. After each Ang II dose, BP stabilized at a significantly higher level in AT_1AMUT mice than in control mice. (B) Ang II dose-response effect on systolic BP. The area under the curve (AUC; see Methods) was measured for each Ang II dose in AT_1AWT (solid line) and AT_1AMUT mice (dotted line). (C) Systolic BP response to increasing bolus doses of CGP42112A injected in anesthetized AT_1AWT (white bars) and AT_1AMUT (black bars) mice. *P < 0.05, **P < 0.01 compared with AT_1AWT.