Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in mice
J. Clin. Invest. Sandrine Billet, et al. 117:1914 doi:10.1172/JCI28764 [
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Figure 2Quantitative RT-PCR of the Ang II receptors in target tissues. RNA from liver, kidney, heart, adrenal gland, and aorta were retrotranscribed and amplified for AT
1A (
A), AT
1B (
B), and AT
2 (
C) mRNAs using the LightCycler technology in AT
1AWT (white bars) and AT
1AMUT (black bars) mice. Results are expressed in arbitrary units relative to the expression of cyclophilin gene in the same tissues. ND, not detectable.
