Impaired regulation of NF-κB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice
J. Clin. Invest. Jun Zhang, et al. 116:3042 doi:10.1172/JCI28746 [
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Figure 6Increased colonic inflammation and tumor development in
Cyld–/– mice.
(
A) Schematic of the AOM and DSS CAC model. (
B) Weight loss during the first cycle of DSS treatment in
Cyld–/– and wild-type mice, expressed as percent of the starting weight for each cohort. (
C) Histologies of
Cyld–/– and wild-type colons, either left untreated or 7 days after the first cycle of DSS treatment. Magnification, ×50. (
D) Survival curves of
Cyld–/– and wild-type mice (
n = 60 per group) injected with AOM followed by DSS. Curves are statistically different (
P < 0.001). (
E) Incidence and total number of tumors (>0.5 mm) in the colons of
Cyld–/– and wild-type mice after administration of AOM followed by DSS. Mice were sacrificed 7 days after the first (left) or the second cycle (right) of DSS treatment. *
P < 0.001;
Cyld–/– versus wild-type. (
F) Typical colon histologies demonstrating broad-based adenocarcinoma in a
Cyld–/– section 7 days after the second cycle of DSS treatment. Magnification, ×50.
